| 多肽类化合物在颅脑创伤中的研究进展 |
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| 引用本文： | 马凯源,章越凡,李铁军. 多肽类化合物在颅脑创伤中的研究进展[J]. 药学实践杂志, 2017, 35(6): 495-498,529 |
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| 作者姓名： | 马凯源 章越凡 李铁军 |
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| 作者单位： | 安徽中医药大学药学院, 安徽 合肥 230012,第二军医大学药学院药理学教研室, 上海 200433,安徽中医药大学药学院, 安徽 合肥 230012;第二军医大学药学院药理学教研室, 上海 200433 |
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| 基金项目： | 上海市卫生和计划生育委员会科研课题（201640404） |
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| 摘 要： | 颅脑创伤每年在全球造成严重的伤亡，至今研究者们依然没有找到有效的临床治疗药物。肽类物质以其安全、易耐受等优势逐渐成为研究开发的热点。对多肽类化合物在颅脑创伤中的神经保护和抗炎作用进行综述。
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| 关 键 词： | 颅脑创伤 肽类药物 神经保护 抗炎 |
| 收稿时间： | 2017-07-17 |
| 修稿时间： | 2017-10-17 |
Research progress of peptide compounds in traumatic brain injury |
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| MA Kaiyuan,ZHANG Yuefan and LI Tiejun. Research progress of peptide compounds in traumatic brain injury[J]. The Journal of Pharmaceutical Practice, 2017, 35(6): 495-498,529 |
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| Authors: | MA Kaiyuan ZHANG Yuefan LI Tiejun |
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| Affiliation: | School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China,Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China and School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Traumatic brain injuries(TBI) have caused severe injuries and deaths all over the world, but so far researchers have not found an effective drug in treating TBI on clinic. However, peptides have gradually been in a hot research with its advantages which include safety and tolerance etc. The neuroprotective and anti-inflammatory effects of several peptide compounds in traumatic brain injury are reviewed in this paper. |
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| Keywords: | traumatic brain injury peptides neuroprotection anti-inflammatory |
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