| 一种新型CO2响应型肿瘤靶向药物传递载体 |
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| 引用本文： | 林静,张瑞,韩淼,吴嘉豪,张振中,任雪玲. 一种新型CO2响应型肿瘤靶向药物传递载体[J]. 医学教育探索, 2017, 30(3): 327-332 |
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| 作者姓名： | 林静 张瑞 韩淼 吴嘉豪 张振中 任雪玲 |
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| 作者单位： | 郑州大学药学院, 郑州 450001;河南省肿瘤重大疾病靶向治疗与诊断重点实验室, 郑州 450001,郑州大学药学院, 郑州 450001;河南省肿瘤重大疾病靶向治疗与诊断重点实验室, 郑州 450001,郑州大学药学院, 郑州 450001,郑州大学药学院, 郑州 450001,郑州大学药学院, 郑州 450001;河南省肿瘤重大疾病靶向治疗与诊断重点实验室, 郑州 450001,郑州大学药学院, 郑州 450001;河南省肿瘤重大疾病靶向治疗与诊断重点实验室, 郑州 450001 |
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| 基金项目： | 国家自然科学基金（81573364）。 |
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| 摘 要： | 将透明质酸（HA）依次接枝1，12-二氨基十二烷和N，N-二甲基乙酰胺二甲缩醛（DADA），构建得到CO2刺激响应的透明质酸-脒基（HA-ami）。为了考察其结构、CO2刺激响应性、细胞水平作为药物载体的可行性和肿瘤靶向性，进行了结构表征、CO2刺激响应性表征、细胞摄取、细胞毒性和体内的组织分布实验。结果表明：HA-ami成功构建，并具有一定的CO2刺激响应性，可携带模型药物摄取进入人乳腺癌细胞（MCF-7），而且没有出现明显的细胞毒性，具有体内肿瘤靶向性。
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| 关 键 词： | 透明质酸 CO2刺激响应性 药物载体 自组装 |
| 收稿时间： | 2017-03-30 |
A Novel CO2 Responsive Tumor Targeting Drug Delivery Carrier |
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| LIN Jing,ZHANG Rui,HAN Miao,WU Jia-hao,ZHANG Zhen-zhong and REN Xue-ling. A Novel CO2 Responsive Tumor Targeting Drug Delivery Carrier[J]. Researches in Medical Education, 2017, 30(3): 327-332 |
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| Authors: | LIN Jing ZHANG Rui HAN Miao WU Jia-hao ZHANG Zhen-zhong REN Xue-ling |
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| Affiliation: | School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001, China;Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases of Henan Province, Zhengzhou 450001, China,School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001, China;Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases of Henan Province, Zhengzhou 450001, China,School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001, China,School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001, China,School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001, China;Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases of Henan Province, Zhengzhou 450001, China and School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001, China;Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases of Henan Province, Zhengzhou 450001, China |
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| Abstract: | Hyaluronic acid (HA) was grafted with 1,12-dodecanediamine and N,N-dimethylacetamide dimethylacetal (DADA), to construct the CO2 stimuli-responsive HA-ami. In order to investigate its structure, CO2 stimuli-responsive, cell level as a drug carrier and its tumor targeting, HA-ami was characterized by structure, CO2 response experimental, cell uptake, cell cytotoxicity, and in vivo tissue distribution. Results indicated that HA-ami was successfully constructed, and had a CO2 stimuli-responsive. Moreover, HA-ami not only showed the high cellular uptake efficacy and insignificant cytotoxicity, and it was capable of in vivo tumor targeting. |
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| Keywords: | hyaluronic acid CO2 stimuli-responsive drug carrier self-assembly |
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