二巯基丙磺酸钠驱汞治疗引起药疹反应199例分析

目的]分析二巯基丙磺酸钠（NaDMPS）在驱汞治疗中所致的药疹反应。方法]对1967-1994年间199例因接触汞导致尿汞增高，并住院采用NaDMPS驱汞治疗后发生药疹反应的病例进行回顾性资料分析。结果]199例住院病例中20例用NaDMPS驱汞治疗后出现躯干、四肢皮肤片状红斑、丘疹药疹反应。药疹发病年龄以19～30岁为主，NaDMPS驱汞治疗第4疗程后药疹发病率普遍增高。结论]NaDMPS驱汞治疗时，第3疗程为关键疗程，如需继续第4疗程驱汞治疗，应严格控制，间隔一定的时间再进行。避免患者由于疗程或次数的增加、药量累积等因素在驱汞治疗中产生药疹反应。

Drug Rash in 199 Cases Caused by NaDMPS Treatment for Dispelling Mercury

Objective]To study the drug rash reactions caused by NaDMPS treatment in mercury exposure cases.Methods] A retrospective analysis was carried out on 199 mercury exposure cases from 1967 through 1994,in them urine mercury concentration was elevated and drug rashes occurred after administration of NaDMPS.Results] In 20 of the 199 cases,longitudinal red spots and rashes were observed on their trunk and extremities whom were subjected to NaDMPS treatment for mercury exposure.The majority of drug rash patient...