神经生长因子及其受体在人胰腺导管癌组织中的表达 |
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引用本文: | 孟令新,丁兆军,陈希平,费立升,迟玉华,赵智刚,王晓芳,郝希山. 神经生长因子及其受体在人胰腺导管癌组织中的表达[J]. 中华内科杂志, 2009, 48(1): 562-565. DOI: 10.3760/cma.j.issn.0578-1426.2009.07.010 |
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作者姓名: | 孟令新 丁兆军 陈希平 费立升 迟玉华 赵智刚 王晓芳 郝希山 |
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作者单位: | 日照市人民医院肿瘤科日照市肿瘤治疗中心,山东日照,276826;天津医科大学肿瘤医院国家"211工程"中心实验室; |
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基金项目: | 国家自然科学基金青年科学基金项目国家自然科学基金面上项目日照市人民医院博士科研启动基金 |
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摘 要: | Objective To investigate nerve growth factor (β-NGF) and its receptors expression in human pancreatic ductal adenocarcinoma. Methods Expression and distribution of β-NGF, tyrosine kinase A (TrKA) and P75NGFR were detected in operation tissue specimens of pancreatic ductal adenocarcinoma with immunohistochemistry and real-time PCR. Relations of β-NGF and its receptors with clinicalpathological characters, especially nerve invasion were analyzed. Results β-NGF and TrKA expression are higher in pancreatic adenocarcinoma than normal pancreas, and the differences are significant (P < 0. 01). Β-NGF and TrKA expression are associated with the differentiation grades(DG), lymphatic node metastasis, nerve invasion and surgical pathological stages. Poorer of DG and later stages, more expression of β-NGF and TrKA. Β-NGF and TrKA expression have positive correlations. Β-NGF, TrKA and P75NGFR mRNA expression have significantly increased 3.84,4. 23 and 2. 41 times than normal tissues by real-time PCR, respectively. Conclusions β-NGF and TrKA might play potential rules in carcinogenesis for pancreatic cancer,have affinity with clinicopathological characters of pancreatic cancer. Β-NGF and TrKA may have mutual effect in signal transduction leading to perineural invasion of pancreatic carcinoma.
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关 键 词: | 神经生长因子 胰腺肿瘤 嗜神经性 疼痛 |
The expression and significance of nerve growth factor and its receptors in pancreatic ductal adenocarcinoma |
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Keywords: | Nerve growth factorPancreatic neoplasmsNerve invasionPain |
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