| 急性脑梗死患者血浆谷胱甘肽过氧化酶浓度的改变及其与GPx-3启动子基因多态性的关系 |
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| 引用本文： | 黄开梅,赵中,陈伟贤,高炳忠,周沁,邱晨红,杨义伟. 急性脑梗死患者血浆谷胱甘肽过氧化酶浓度的改变及其与GPx-3启动子基因多态性的关系[J]. 临床神经病学杂志, 2009, 22(4) |
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| 作者姓名： | 黄开梅 赵中 陈伟贤 高炳忠 周沁 邱晨红 杨义伟 |
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| 作者单位： | 南京医科大学附属苏州医院神经内科,苏州,215001;南京医科大学第一附属医院神经内科;江苏金坛市人民医院检验科 |
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| 基金项目： | 江苏省苏州市科技局社会发展项目基金(SZD0795) |
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| 摘 要： | 目的探讨急性脑梗死(ACI)患者血浆谷胱甘肽过氧化酶(GPx)浓度的改变及其与GPx-3启动子基因多态性的关系。方法检测94例ACI患者和80例正常对照者血浆GPx浓度。在ACI患者发病第1d进行神经功能缺损程度评分(NDS)。采用聚合酶链反应-连接酶检测方法(PCR-LDR)检测ACI患者GPx-3启动子基因多态性。结果ACI组发病第1d血浆GPx浓度明显低于正常对照组(P<0.01),发病第14d时血浆GPx浓度与正常对照组比较,差异无统计学意义(P>0.05)。有GPx-3启动子基因多态性的ACI患者,血浆GPx浓度和NDS明显低于无GPx-3启动子基因多态性的患者(P<0.05～0.01)。结论ACI患者血浆GPx浓度明显降低,有GPx-3基因多态性的患者血浆GPx浓度下降更明显,神经功能缺损程度更重。
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| 关 键 词： | 脑梗死 谷胱甘肽过氧化酶 基因多态性 |
Change and its correlation between plasma concentration of glutathione peroxidase and polymorphisms of glutathione peroxidase promoter gene in patients with acute cerebral infarction |
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| HUANG Kai-mei,ZHAO Zhong,CHEN Wei-xian,et al.. Change and its correlation between plasma concentration of glutathione peroxidase and polymorphisms of glutathione peroxidase promoter gene in patients with acute cerebral infarction[J]. Journal of Clinical Neurology, 2009, 22(4) |
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| Authors: | HUANG Kai-mei ZHAO Zhong CHEN Wei-xian et al. |
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| Affiliation: | HUANG Kai-mei,ZHAO Zhong,CHEN Wei-xian,et al.Department of Neurology,the Suzhou Hospital Affiliated to Nanjing Medical University,Suzhou 215001 China |
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| Abstract: | Objective To study the change and its correlation between plasma concentration of glutathione peroxidase and polymorphisms of the glutathione peroxidase(GPx-3) promoter gene in patients with acute cerebral infarction(ACI).Methods 94 patients with ACI and 80 normal controls were detected the concentration of plasma glutathione peroxidas.The patients with ACI were undertaken neural function deficient scale(NDS) after 1 d onset.GPx-3 gene polymorphism were detected using polymerase chain reaction and ligase de... |
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| Keywords: | cerebral infarction glutathione peroxidase gene polymorphisms |
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