| 日本血吸虫24—26kDa抗原和重组Sj26抗原的... |
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| 引用本文： | 刘述先 宋光承. 日本血吸虫24—26kDa抗原和重组Sj26抗原的...[J]. 中国寄生虫学与寄生虫病杂志, 1992, 10(3): 190-193 |
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| 作者姓名： | 刘述先 宋光承 |
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| 摘 要： |
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| 关 键 词： | 抗原 血吸虫 抗原性 免疫原性 |
Comparative study on antigenicity and immunogenicity of the 24-26 kDa antigen and the recombinant Sj26 antigen of Schistosoma japonicum] |
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| S X Liu,G C Song,L Y Ding,Y X Xu,G Z Wu. Comparative study on antigenicity and immunogenicity of the 24-26 kDa antigen and the recombinant Sj26 antigen of Schistosoma japonicum][J]. Chinese Journal of Parasitology and Parasitic Diseases, 1992, 10(3): 190-193 |
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| Authors: | S X Liu G C Song L Y Ding Y X Xu G Z Wu |
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| Affiliation: | Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai. |
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| Abstract: | This paper reports on the comparison of the recombinant Sj26 (rSj26) antigen originated from the Philippine strain and 24-26 kDa antigen isolated and purified from Chinese mainland strain of S. japonicum for their antigenicity and immunogenicity. The results showed that there were obvious cross reactions between rSj26 and 24-26 kDa antigen when rSj26 antigen was tested against specific antibodies in sera from mice infected with the mainland strain of S. japonicum or 24-26 kDa antigen was tested against specific anti-rSj26 antibodies by ELISA, IFA and Western blotting etc. Both of 24-26 kDa and rSj26 antigen had weak cross reaction with SEA antigen. The worm reduction rate after challenging with mainland strain cercariae in mice immunized with rSj26 was 26-32%, similar to that in mice immunized with 24-26 kDa antigen. It is suggested that rSj26 antigen can induce certain level of specific protective immunity to protect the host against infection by Chinese strain of S. japonicum cercaciae. |
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