微量元素铜和锌在实验性肝癌中的变化及意义

探讨微量元素铜和锌在二乙基亚硝胺诱发大鼠实验性肝癌中的变化及意义。用原子吸收光谱法观察血清中微量元素铜和锌的含量 :用分析电镜对实验组与对照组肝组织中微量元素铜和锌进行了原位定性定量分析。结果 :与对照组相比 ,实验组中血清铜水平升高 ,血清锌水平降低及血清铜 /锌比值 ( 1 .53)显著高于对照组 ( 0 .78) ( P<0 .0 5) ,实验组肝癌组织中微量元素铜和锌含量明显低于对照组正常肝组织 ( P<0 .0 5)。结论 :微量元素铜和锌的变化与肝癌的发生发展密切相关 ,血清铜 /锌比值升高可作为肝癌的一个重要标志。

Significance of trace elements copper and zinc change in experimental hepatocarcinoma

Objective To elucidate the change and significance of the trace elements copper and zinc of experimental hepatocarcinoma induced diethyinitrosamine in rats.Methods We studied both the trace elements copper and zinc in serum of test group and control group by the atomic absorption spectrophotometer and that the trace elements copper and zinc in experimental hepatocarcinoma and normal liver tissues by the electron probe microanalysis,respectively.results The content of the trace elements copper and zinc in tissues of test group was significantly (P<0 05)lower than that of control group.Compared wwith control group,the serum copper levels increased and serrum zinc levels decreased in test group.The serum Cu/Zn ratio of test group (1.53) was significantly (0.78) highter than that of control group (P<0 05).Conchtsions These results indicate that the change of the trace elements copper and zinc was cosely related to the genesis and development of hepatocarcinoma,the serum Cu/Zn ratio may be used as a vaaluble marker of hepatocarcinoma.