离子色谱法测定肝素钠中草酸根的含量

目的 加强肝素钠的质量控制,建立草酸根检测方法.方法 采用离子色谱法对肝素钠中草酸根离子进行测定,并进行方法学验证.结果 线性相关系数r=0.9998,加样回收率为95.2%～99.7%,检测40批肝素钠原料发现部分草酸根离子含量较高.结论 本方法操作简单,结果准确,灵敏度高,可对肝素钠进行更进一步的质量控制.

Determination of Oxalic Ion in Heparin Sodium by Ion-chromatography

Objective To establish a method to determine oxalic ion in heparin sodium, and to improve its quality control. Methods The oxalic ion in heparin sodium was determined by ion-chromatography, Results The linear coefficientcorrelation was 0.9998, and the recovery rate was 95.2%～99.7%. A total of 40 hatches of heparin sodium were tested. The content of oxalic ion in some of those batches was relatively high. Conclusion The method is simple and accurate.