| 单光子发射计算机断层扫描评价阿霉素对非霍奇金淋巴瘤患者的心肌毒性(附44例分析) |
| |
| 引用本文： | 樊卫,张力,梁培炎,张伟光,冯祝玲. 单光子发射计算机断层扫描评价阿霉素对非霍奇金淋巴瘤患者的心肌毒性(附44例分析)[J]. 新医学, 1998, 29(11): 573-574 |
| |
| 作者姓名： | 樊卫 张力 梁培炎 张伟光 冯祝玲 |
| |
| 作者单位： | 中山医科大学肿瘤中心,510060 |
| |
| 摘 要： | 目的 :探讨 SPECT心功能测定评价非霍奇金淋巴瘤 (NHL )化疗后阿霉素 (ADM)心肌毒性的可行性。方法 :选择无心脏病基础的 4 4例 NHL患者作研究对象 ,采用常规 CHOP方案进行治疗。定期用 SPECT检测患者的心功能。结果 :化疗前后射血分数 (EF)、高峰射血率 (PER)和高峰充盈率 (PER)值比较 ,差别有显著性 (P<0 .0 5 ) ;体内 ADM累积量愈大 ,EF、PER和 PER值下降愈大 ,并以 PFR变化最敏感。结论 :SPECT心功能测定是评价 NHL患者 ADM心肌毒性的敏感、适用的方法。
|
| 关 键 词： | 心功能 淋巴瘤,非霍奇金 阿霉素 心肌毒性 |
| 修稿时间： | 1998-06-08 |
Determination of adriamycin induced cardiotoxicity by SPECT in patients with non-Hodgkin lymphoma:a preliminary report of 44 cases |
| |
| Fan Wei,Zhang Li,Liang Peiyan,et al.. Determination of adriamycin induced cardiotoxicity by SPECT in patients with non-Hodgkin lymphoma:a preliminary report of 44 cases[J]. New Chinese Medicine, 1998, 29(11): 573-574 |
| |
| Authors: | Fan Wei Zhang Li Liang Peiyan et al. |
| |
| Affiliation: | Fan Wei,Zhang Li,Liang Peiyan,et al. Cancer Canter of Sun Yat-Sen University of Medical Science,Guangzhou,510060 |
| |
| Abstract: | Objective: To evaluate the possibility of determination of adriamycin (ADM)induced cardiotoxicity by SPECT. Methods: SPECT was performed in 44 patients with non-Hodgkin lymphoma (NHL) and without underlying cardiac problems, who received standard CHOP chemotherapy. Results: There were significantly differences before and after treatment with ADM in EF, PER, or PFR. The decrease in EF, PER and PFR was inversely correlated to the accumulated dosage of ADM, with the PFR being the most sensitive. Conclusions: SPECT is a sensitive and useful method in determining ADM induced cardiotoxicity. |
| |
| Keywords: | Non-Hodgkin lymphoma Single photon emission computed tomography Adriamycin Cardiotoxicity |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
