中药对中枢神经退行性疾病信号通路影响的研究进展 |
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作者姓名: | 张丽娜 张欣 薛娟 张丹参 |
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作者单位: | 1. 河北医科大学药学院,石家庄,050011,中国
2. 河北大学医学院,保定,071000,中国 |
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摘 要: | 随着对中药防治中枢神经系统衰老相关疾病发病机制的深入探讨,发现中药通过信号分子Wnt、β-catenin、TCF/ LEF、磷脂酰肌醇3 激酶( phosphatidylinositol-3 kinase,PI3K)、蛋白激酶B( protein kinase B,AKT)、哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)、核因子-κB(nuclear factor kappa B,NF-κB),细胞色素C(cytochrome,Cyt-C)、B 淋巴细胞瘤-2(B-cell lymphoma-2,Bcl-2)家族蛋白、Caspases 酶等,调节Wnt/β-catenin、PI3K/Akt、线粒体凋亡信号通路,发挥对阿尔茨海默病(Alzheimer’s disease,AD)、帕金森病(Parkinson’s disease,PD)、脑缺血等衰老相关中枢神经系统疾病的防治作用。该文着重从以上三条信号通路,对中药在中枢神经系统退行性疾病的防治现状做一阐述。
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关 键 词: | Wnt/&beta -catenin 信号通路 线粒体凋亡 PI3K/Akt 信号通路 阿尔茨海默病 帕金森病 |
Advances Achievements of Traditional Chinese Medicine on the Signaling Pathways in Central Nervous Degenerative Diseases |
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Authors: | ZHANG Li-na ZHANG Xin XUE Juan ZHANG Dan-shen |
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Institution: | 1. School of Pharmacy,Hebei Medical University,Shijiazhuang,050011,China
2. College of Medical,Hebei University,Baoding,071000,China |
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Abstract: | It is found that Chinese medicine play a important role in the prevention and treatment of the central nervous system diseases(AD,PD,cerebral ischemia,etc) by adjusting the key signaling molecule such as Wnt,β-catenin,TCF/LEF,PI3K,AKT,mTOR,NF-κB,Cyt-C,Bcl-2 family,Caspases enzyme,etc,along with in-depth study of the pathogenesis on Chinese medicine used to delay aging and prevent age-related diseases. This article focuses on three signaling pathways (Wnt/β-catenin,PI3K/Akt,mitochondrial apoptosis) and reviews the prevention and treatment of Chinese medicine on the central nervous system degenerative diseases mainly. |
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Keywords: | Wnt/&beta -catenin signaling pathway mitochondrial apoptosis PI3K/Akt signaling pathway Alzheimer&rsquo s disease( AD) Parkinson&rsquo s disease( PD) |
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