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| 新型冠状病毒引起的病毒性角膜炎病例观察 | |
| 引用本文： | 谢孟针,张浩,马可,殷鸿波,王力翔,唐静. 新型冠状病毒引起的病毒性角膜炎病例观察[J]. 国际眼科杂志, 2024, 24(4): 495-499 |
| 作者姓名： | 谢孟针 张浩 马可 殷鸿波 王力翔 唐静 |
| 作者单位： | 中国四川省成都市,四川大学华西医院眼科; 中国四川省成都市,四川大学华西临床医学院 |
| 基金项目： | 四川省科技计划项目(No.2021YFS0221); 四川大学华西医院1.3.5临床孵化项目(No.2022HXFH032,2021-023,2022-014) |
| 摘 要： | 目的：报告3例严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的病毒性角膜炎。 方法：对3例新冠感染确诊患者行裂隙灯、眼压、角膜荧光染色、前段照相、活体共聚焦显微镜(IVCM)和常规眼底筛查。治疗包括更昔洛韦眼用凝胶、人工泪液和糖皮质激素滴眼液。 结果：3例SARS-CoV-2角膜炎(SCK)患者经标准治疗后恢复良好。 结论：SARS-CoV-2角膜炎通常表现为角膜上皮下浸润，可导致角膜上皮下神经纤维密度降低和树突状细胞(DC)增加。抗病毒治疗联合糖皮质激素已被证明是有效的。 |
| 关 键 词： | 角膜炎 COVID-19 SARS-CoV-2 更昔洛韦 |
| 收稿时间： | 2023-02-01 |
| 修稿时间： | 2024-01-15 |
Case observation of viral keratitis caused by SARS-CoV-2 |
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| Xie Mengzhen,Zhang Hao,Ma Ke,Yin Hongbo,Wang Lixiang,Tang Jing. Case observation of viral keratitis caused by SARS-CoV-2[J]. International Eye Science, 2024, 24(4): 495-499 | |
| Authors: | Xie Mengzhen Zhang Hao Ma Ke Yin Hongbo Wang Lixiang Tang Jing |
| Affiliation: | Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China; West China School of Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China |
| Abstract: | AIM: To report three cases of viral keratitis caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). METHODS: Slit lamp, intraocular pressure, corneal fluorescence staining, anterior segment photography, in vivo confocal microscopy(IVCM), and routine fundus screening were performed in the three confirmed patients. Treatment involved Ganciclovir, artificial tears and glucocorticoid eye drops. RESULTS: Three patients with SARS-CoV-2 keratitis(SCK)recovered well after standard treatment. CONCLUSION: SARS-CoV-2 keratitis typically presents as corneal subepithelial infiltration and can result in a decrease in corneal subepithelial nerve fiber density and an increase in dendritic cells(DC). Antiviral therapy in combination with glucocorticoid has proven to be effective. |
| Keywords: | keratitis COVID-19 SARS-CoV-2 Ganciclovir |
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