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上海市50岁及以上人群维生素D水平与握力的关联研究
引用本文:董俣君,郭雁飞,阮晔,孙双圆,蒋安丽,汪嘉琦,施燕,吴凡. 上海市50岁及以上人群维生素D水平与握力的关联研究[J]. 中华流行病学杂志, 2024, 45(3): 393-400
作者姓名:董俣君  郭雁飞  阮晔  孙双圆  蒋安丽  汪嘉琦  施燕  吴凡
作者单位:上海市疾病预防控制中心慢性非传染病与伤害防治所, 上海 200336;上海市预防医学研究院, 上海 200336;复旦大学上海医学院, 上海 200032
基金项目:美国国立老龄研究所(R01-AG034479);上海市卫生健康委员会项目(20204Y0196,2020YJZX0113,GWVI-8,GWVI-11.1-22,GWVI-11.1-25,201840118)
摘    要:目的 探讨上海市≥50岁人群维生素D水平与握力的关系。方法 数据来源于WHO全球老龄化与成人健康研究我国上海市2018-2019年数据,采用logistic回归模型分析维生素D水平与握力的关系,进一步按照性别、年龄及乳制品摄入情况进行分层;采用限制性立方样条曲线绘制维生素D水平与低握力的剂量-反应曲线。结果 共4 391人纳入研究,其中男性2 054人(46.8%);年龄(67.02±8.81)岁;低握力1 421人(32.4%);维生素D不足及缺乏分别为1 533人(34.9%)和401人(9.1%)。在调整相关混杂因素后,logistic回归分析结果显示,维生素D缺乏的人群发生低握力的风险更高(OR=1.41,95%CI:1.09~1.83);在男性中,调整相关混杂因素后,维生素D缺乏与低握力发生风险呈显著正相关(OR=1.67,95%CI:1.12~2.50),而女性中两者之间无关联(OR=1.30,95%CI:0.97~1.74);在60~69岁及≥80岁年龄组中,调整相关混杂因素后,维生素D缺乏与低握力发生风险呈显著正相关(OR=1.57,95%CI:1.05~2.35;OR=2.40,95%CI:1.08~5.31),在乳制品摄入<250 ml/d的人群中,调整相关混杂因素后,二者之间呈显著正相关(OR=1.57,95%CI:1.17~2.09),而在乳制品摄入≥250 ml/d的人群中无明显关联。限制性立方条样图显示,低握力的发生风险可能随维生素D含量的上升而降低,但差异无统计学意义(P>0.05)。结论 维生素D水平与握力存在一定的关系,维生素D缺乏人群出现低握力的风险更高。

关 键 词:维生素D  握力  中老年人
收稿时间:2023-06-30

Association between vitamin D level and grip strength in adults aged 50 and older in Shanghai
Dong Yujun,Guo Yanfei,Ruan Ye,Sun Shuangyuan,Jiang Anli,Wang Jiaqi,Shi Yan,Wu Fan. Association between vitamin D level and grip strength in adults aged 50 and older in Shanghai[J]. Chinese Journal of Epidemiology, 2024, 45(3): 393-400
Authors:Dong Yujun  Guo Yanfei  Ruan Ye  Sun Shuangyuan  Jiang Anli  Wang Jiaqi  Shi Yan  Wu Fan
Affiliation:Division of Chronic and Non-communicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China;Shanghai Institute of Preventive Medicine, Shanghai 200336, China; Office for Shanghai Medical College, Fudan University, Shanghai 200032, China
Abstract:Objective To understand the association between vitamin D level and grip strength in people aged ≥50 years in Shanghai. Methods Data were obtained from the WHO''s Study on Global Ageing and Adult Health in Shanghai during 2018-2019. Logistic regression model was used to analyze the association between vitamin D level and grip strength, and a stratified analysis was conducted for different gender, age and dairy product intake groups. Restricted cubic spline was used to evaluate the dose-response association between vitamin D level and low grip strength. Results A total of 4 391 participants were included in the study, including 2 054 men (46.8%), with an average age of (67.02±8.81) years. And 1 421 individuals (32.4%) had low grip strength; 1 533 individuals (34.9%) had vitamin D deficiency, and 401 individuals (9.1%) had vitamin D deficiency. After adjusted for confounding factors, the logistic regression results analysis showed that individuals with vitamin D deficiency had a higher risk for low grip strength (OR=1.41, 95%CI: 1.09-1.83). In men, after adjusting for confounding factors, vitamin D deficiency was positively associated with the risk for low grip strength (OR=1.67, 95%CI: 1.12-2.50), but there was no significant association between vitamin D level and grip strength in women (OR=1.30, 95%CI: 0.97-1.74). In age group 60-69 years and ≥80 years, there was significant association between vitamin D deficiency and low grip strength after adjusting for confounding factors (OR=1.57, 95%CI: 1.05-2.35; OR=2.40, 95%CI: 1.08-5.31). In people who had daily intake of dairy product <250 ml, there was positive association between vitamin D deficiency and low grip strength, but there was no significant association in people who had daily dairy product ≥250 ml after adjusting for confounding factors. The restrictive cubic spline demonstrated that risk of low grip strength might decreased with the increase of vitamin D levels, however, the difference was not significant (P>0.05). Conclusions This study demonstrated that there is association between vitamin D level and grip strength. People with vitamin D deficiency have higher risk for low grip strength.
Keywords:Vitamin D  Grip strength  Middle-aged and elderly people
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