The provocation of coronary arterial spasm in patients with recent transmural myocardial infarction |
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Authors: | M E Bertrand J M Lablanche P Y Tilmant F A Thieuleux M G Delforge R A Chahine |
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Affiliation: | *Division of Cardiology and Haemodynamics, University Hospital Lille, France Baylor College of Medicine Houston, Texas, U.S.A. |
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Abstract: | Provocative tests for coronary spasm were performed in a groupof 131 patients (124 men and 7 women) with recent (<6 weeks)transmural myocardial infarction. Coronary arteriography wasperformed 27±9 days after the onset of the infarction.The provocative test was performed using a single IV bolus of0.4 mg of ergometrine. Aortic pressure, ECG and arteriogramsof the two coronary vessels were repeated 3 and 5 min later.Provoked spasm was observed in 27 (21%) of the patients. In13 (48%) the coronary spasm occurred in a vessel presumed tobe responsible for the myocardial infarction, while it was observedin coronary artery unrelated to the area of the infarct in 14(52% of the cases with spasm). Thus, this study demonstratesa high degree of reactivity of the coronary tree of patientswith recent transmural myocardial infarction suggesting thelikelihood of a role for spasm in the infarction process andoffering some explanation for subsequent recurrent ischemicevents. |
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Keywords: | Myocardial infarction coronary spasm |
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