喉癌中环氧化酶-2和p53的表达及相关性研究

目的 :了解喉癌组织中环氧化酶 2 (Cox 2 )及p5 3的表达 ,探讨Cox 2在喉癌发生发展中的作用及与p5 3之间的关系。 方法 :采用免疫组织化学方法检测 6 3例喉癌组织中Cox 2与 p5 3的表达情况。 结果 :6 3例喉癌标本中Cox 2阳性表达率为 5 8.7% (37/6 3) ,患者的不同临床分期的表达差异有统计学意义 (P <0 .0 5 )。p5 3的阳性表达率为 6 3.5 % (4 0 /6 3) ,不同组织病理学分级的 p5 3阳性表达的差异有统计学意义 (P <0 .0 5 ) ;Cox 2与p5 3之间存在等级相关性。结论 :Cox 2能促进喉癌的生长、增殖与浸润 ,应用Cox 2抑制剂可望对喉癌的发展起到抑制作用

Expression of cyclooxygenase-2 and p53 and their correlation in carcinoma of larynx

Objective:To study the expression of cyclooxygenase-2 in laryngeal squamous carcinoma and evaluate the relation between cyclooxygenase-2 and p53.Method:The pathological sections of laryngeal squamous carcinoma was examined by using the method of immunohistochemistry.Result:Overexpression of Cox-2 and p53 were found in the laryngeal squamous carcinoma specimens; the positive rates of cyclooxygenase-2 and p53 protein expression were 58.7% (37/63) and 63.5% (40/63), respectively. The positive expressions of Cox-2 were related to the clinical stage. The positive expressions of p53 were related to histological grade. There was a positive relationship between Cox-2 and p53.Conclusion:Cyclooxygenase-2 plays an important roles in the process of development, growth and invasion of laryngeal squamous carcinoma; and its inhibitors maybe have effect on the development of laryngeal squamous carcinoma.