来氟米特联合甲氨蝶呤治疗类风湿性关节炎的疗效和安全性分析

目的 观察来氟米特联合甲氨蝶呤治疗类风湿性关节炎的疗效和安全性.方法 将120例活动性RA患者随机分为治疗组和对照组,每组各60例.治疗组口服来氟米特和甲氨蝶呤,对照组口服甲氨蝶呤,比较两组的疗效和不良反应.结果 治疗组总有效率为88.3％,对照组总有效率为71.7％,两组比较差异有统计学意义（P＜0.05）;治疗组不良反应发生率为25％,对照组不良反应发生率为20％,两组比较无统计学意义（P＞0.05）.结论 来氟米特联合甲氨蝶呤治疗类风湿关节炎临床效果好,值得推广.

Leflunomide combined with methotrexate in treatment of Rheumatoid Arthritis

Objective To explore the efficacy and safety of leflunomide combined with methotrexate in the treatment of rheumatoid arthritis. Methods 120 patients with active rheumatoid arthritis were randomly divided into a treatment group（n=60） and a control group（n=60）. The treatment group was treated with leflunomide and methotrexate, while the control group with only methotrexate. The efficacies and adverse reactions compared between two groups. Results The total effective rate was 88.3% in the treating group and was 71.7% in the control group, with a statistical difference（P〈0.05）. The incidence of adverse reactions was 25% in the treating group and was 20% in the control group, with no statistical difference （P〉O.05）. Conclusion Leflunomide combined with methotrexate in the treatment of rheumatoid arthritis is effective and worth being clinically generalized