泛素特异性肽酶22基因与肿瘤发展和预后的研究进展 |
| |
引用本文: | 庄雅靖,喻芳,周同冲. 泛素特异性肽酶22基因与肿瘤发展和预后的研究进展[J]. 国际医药卫生导报, 2014, 0(17): 2627-2631 |
| |
作者姓名: | 庄雅靖 喻芳 周同冲 |
| |
作者单位: | 广州医科大学附属肿瘤医院,510095 |
| |
基金项目: | 广州医科大学附属肿瘤医院重大专项(2011-gy-06);广州医科大学青年项目(2012A15) |
| |
摘 要: | 泛素特异性肽酶22(ubiquitin—specificprocessingpeptidase22,USP22)是一种新型的去泛素化酶家族基因,是hSAGA复合物的亚单位。越来越多的实验研究结果证明泛素特异性肽酶22(USP22)是癌干细胞标记物中的一种,在肿瘤形成及发展的病理过程中扮演关键的角色,并与不良预后有着密切的关系。
|
关 键 词: | USP22 癌干细胞标记物 肿瘤形成及发展 不良预后 |
Research progress of relationship between ubiquitin specific peptidase 22 gene and process and prognosis of cancer |
| |
Affiliation: | Zhuang Yajing, Liao Zhiwei, Yu Fang, Zhou Tongcbong. (Tumor Hospital Affiliated of Gnangzhou Medical College, Guangzbou 510095, China) |
| |
Abstract: | Ubiquitin specific peptidase 22 (ubiquitin-specific processing peptidase 22, USP22), a novel deubiquitinating enzyme, is one subunit of hSAGA complexes. More and more studies have proved that USP22 is one of a small set of cancer stem cell markers, which plays a key role in the pathological process of various malignant tumors' formation and development and is closely associated with poor prognosis. |
| |
Keywords: | Ubiquitin specific peptidase 22 Cancer stem cell marker Tumors' formation anddevelopment Poor prognosis |
本文献已被 维普 等数据库收录! |