重症急性胰腺炎持续血液净化治疗观察

目的探讨持续性血液净化技术在重症急性胰腺炎治疗中的效果。方法23例患者接受传统临床药物治疗，23患者在此基础上加上持续性血液净化技术，对比两组患者炎性因子等指标改善的情况。结果治疗24h后，观察组IL-1、IL-6、IL-8、TNF-α分别为（246．52±31．84）pg／ml、（15．12±1．07）pg／ml、（16．05±1．08）pg／ml、（1．42±0．31）ng／L，治疗48h后，观察组IL-1、IL-6、IL-8、TNF-α分别为（190．46±27．65）pg／ml、（11．07±1．87）pg／ml、（11．04±1．57）pg／ml、（0．68±0．34）ng／L，均显著低于治疗前，差异有统计学意义（P〈0．05），且观察组指标明显低于对照组。治疗24h后，观察组Ang-Ⅰ、Ang-Ⅱ、E、ALD分别为（1．34±1．17）ng／L、（0．72±5．37）ng／L、（1．05±0．21）ng／ml、（145．27±15．34）pg／ml，治疗48h后，观察组Ang-Ⅰ、Ang-Ⅱ、E、ALD分别为（9．28±1．16）ng／L、（48．42±4．10）ng／L、（0．63±0．11）ng／ml、（99．31±11．16）pg／ml，均显著低于治疗前，差异有统计学意义（P〈0．05），且观察组指标明显低于对照组。结论CBP可以明显缓解SAP病情，促进炎性因子和RAAS系统的改善。

Clinical observation on continuous blood purification therapy in treatment of severe acute pancreatitis

Objective To investigate the effect of continuous blood purification therapy in treatment of severe acute pancreatitis （SAP）. Methods 23 patients were treated with traditional clinical medicine, 23 patients were treated on the basis of the former, with continuous blood purification （CBP） technology added, the inflammatory factors and other indicators of the situation in both groups were compared. Results There was significant difference of IL-1, IL- 6, IL- 8 and TNF- α treatment of two groups of patients in the time of 24h and 48h after treatment （P 〈 0.05）, observed indexes were significantly lower than those of the control group IL-1, IL-6, IL-8, TNF- α were （246.52 ± 31.84） pg/ml, （15.12 ± 1.07） pg/ml, （16.05 ±1.08） pg/ml and （1.42 ± 0.31） ng/L 24 h after treatment （190.46 ± 27.65） pg/ml, （11.07± 1.87） pg/ml, （11.04 ± 1.57） pg/ml and （0.68 ± 0.34） ng/L 48 h after treatment respectively]. There was significant difference of Ang- Ⅰ, Ang- Ⅱ, E, aldosterone in the treatment of the two groups patients in the time of 24 h and 48 h after treatment （P 〈 0.05） Ang-Ⅰ, Ang-Ⅱ, E, ALD were （1.34 ±1.17） ng/L, （0.72 ± 5.37） ng/L, （1.05 ± 0.21） ng/ml and （145.27 ± 15.34） pg/ml 24 h later, （9.28 ±1.16） ng/L, （48.42 ± 4.10） ng/L, （0.63 ± 0.11） ng/ml and （99.31 ±11.16） pg/ml 48 h later]. Conclusion CBP can obviously alleviate the severity of SAP, and promote the inflammatory factors and improve the renin-angiotensin-aldosterone system.