小剂量激素吸入与噻托溴铵联用对支气管哮喘患者血清细胞因子及肺功能的影响

目的探讨小剂量激素吸入与噻托溴铵联用对支气管哮喘患者血清细胞因子及肺功能的影响及临床疗效。方法选择轻、中度哮喘患者80例，随机分为观察组和对照组各40例，观察组采用小剂量二丙酸倍氯米松吸入与噻托溴铵联合治疗，对照组采用大剂量二丙酸倍氯米松治疗，比较两组患者血清细胞因子、肺功能及哮喘症状评分变化情况。结果治疗后观察组IL-8、IL-10、TNF-α明屁低于对照组（P〈0．05），FVC、FEVl、FEVl／FVC明显高于对照组（P〈0．05），哮喘评分明冠低于对照组（P〈O．05），不良反应发生率低于对照组（P〈0．05）。结论小剂量激素吸入联合噻托溴铵治疗支气管哮喘，临床疗效佳，安全可靠，值得临床推广。

Effect of low dose of inhaled corticosteroid combined with tiotropium bromide on cytokines and pulmonary function of patients with bronchial asthma

Objective To investigate clinical efficacy of low dose of corticosteroid combined with tiotropium bromide on cytokines and pulmonary function of patients with bronchial asthma treated by inhaling. Methods 80 cases of patients with light or moderate asthma were randomly divided into observation group and control group, 40 cases for each group. Observation group was treated with inhaling law dose of two beclmnethasone dipropionate and tiotropium bromide, control group was treated with high dose of two beclomelhasone. The cytokines, pulmonary function and asthma symptom score changes between two groups were compared. Results At past-treatment, the IL-8, IL-IO, TNF-a in observation group were significantly lower than those in control group （P 〈 0.05）; the FVC, FEVl, FEV1/FVC （%） in observation group were significantly higher than those in control group （P 〈 0.05）; asthma score was significantly lower than that in control group （P 〈 0.05）; the incidence of adverse reaction was lower than that in control group （P 〈 0.05）. Conclusion Treating bronchial asthma by inhaling low dose of corticosteroid combined with tiotropium bromide has good clinical curative effect, which is safe and reliable, and worthy of clinical application.