某三甲医院实施抗菌药物临床应用专项整治前后应用情况比较

目的 评价专项整治活动开展前后抗菌药物临床应用情况.方法 收集该院抗菌药物专项整治前,即2010年1月至2011年6月抗菌药物使用相关数据;与整治后2011年7月至2013年8月抗菌药物使用相关数据进行统计分析.结果 （1）实施专项整治后,该院抗菌药物使用日趋合理.监测指标中,住院患者抗菌药物使用率、抗菌药物使用强度、Ⅰ类切口抗菌药物预防使用率、外科手术预防使用抗菌药物时间在0.5～2h符合率及Ⅰ类切口手术预防用药疗程符合率整治前后差异有统计学意义（P＜0.05）.（2）该院铜绿假单胞菌和金黄色葡萄球菌耐药率在抗菌药物专项整治前后,经W检验差异有统计学意义（P＜0.05）.结论 抗菌药物专项整治非常有必要,通过专项整治,抗菌药物的使用更加合理.

Comparison on antibiotics clinical application in a grade three hospital before and after the implementation of the special rectification activity

Objective To evaluate the current status of clinical application of antibiotics pre-and post-special rectification activities.Method The data of antibiotics use pre-special activities （from January 2010 to June 2011） and post-Special activities （from July 2011 to August 2013） were collected and compared.Results There was a remarkable improvement on the rationality of antibiotics use in post-special activities.The monitoring index,the utilization rate of antibacterial drugs in hospitalized patients antibacterial use density,the prophylaxis usage of the Class Ⅰ incision antimicrobial drug,the time compliance rate of the prophylaxis usage of antimicrobial drug for surgical operations,which should be between 0.5-2 h,and the compliance rate of surgical prophylaxis treatment of Class Ⅰ incision,with W test,the difference of the monitoring index between pre-and post-special activities was statistically significant （P ＜ 0.05）.The difference of pseudomonas aeruginosa and staphylococcus aureus resistant rate was statistically significant （P ＜ 0.05） with W test.Conclusion Special activities on antibiotics use is very necessary,it can accelerate clinical use of antimicrobial drugs.