Synthesis and antioxidant activity evaluation of new hexahydropyrimido[5,4-c]quinoline-2,5-diones and 2-thioxohexahydropyrimido[5,4-c]quinoline-5-ones obtained by Biginelli reaction in two steps |
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Authors: | Ismaili Lhassane Nadaradjane Arulraj Nicod Laurence Guyon Catherine Xicluna Alain Robert Jean-François Refouvelet Bernard |
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Affiliation: | Equipe Sciences séparatives et Biopharmaceutique (2SB), Laboratoire de chimie thérapeutique, Faculté de Medecine et de Pharmacie, 4, place Saint Jacques - 25030 Besan?on Cedex, France. lhassane.ismaili@univ-fcomte.fr |
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Abstract: | New hexahydropyrimido[5,4-c]quinoline-2,5-diones and 2-thioxohexahydropyrimido[5,4-c]quinoline-5-ones were prepared in two steps from ethyl 4-phenyl-6-methyl-2-oxo tetrahydropyrimidine-5-carboxylates or 4-phenyl-6-methyl-2-thioxotetrahydropyrimidine-5-carboxylates, previously prepared by Biginelli reaction using appropriate aldehyde, urea derivatives and ethyl acetoacetate. Their antioxidant properties were evaluated by two methods: scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and scavenging effect on hydroxyl radicals. The results show that the compounds containing thiourea moiety have better activity. |
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