| 病理性瘢痕组织中c-fos和5-HT表达及与其增生和痛痒的关系 |
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| 引用本文： | 陈振雨,张维娜,苗嫄昕,魏爱华.病理性瘢痕组织中c-fos和5-HT表达及与其增生和痛痒的关系[J].齐鲁医学杂志,2006,21(5):377-379. |
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| 作者姓名： | 陈振雨 张维娜 苗嫄昕 魏爱华 |
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| 作者单位： | 青岛大学医学院附属医院整形美容科,山东,青岛,266003;胜利油田中心医院皮肤科 |
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| 摘 要： | 目的通过对病理性瘢痕组织中c-fos和5-HT表达变化的研究,探讨其与病理性瘢痕痛痒和增生的关系。方法利用免疫组化方法检测病理性瘢痕和正常皮肤中c-fos和5-HT的表达情况。结果痛痒的病理性瘢痕组织中c-fos、5-HT的表达显著高于正常皮肤组织和非痛痒的瘢痕组织(F=19.86、17.61,q=5.43~8.84,P<0.01);非痛痒的瘢痕组织中c-fos的表达显著高于正常皮肤(q=3.41,P<0.01),而5-HT表达无明显差异(P>0.05)。结论c-fos、5-HT表达增高可能导致病理性瘢痕临床痛痒症状的发生,c-fos表达增高可能与病理性瘢痕的形成、发展有关。
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| 关 键 词： | 瘢痕 原癌基因蛋白质c-fos 血清素 疼痛 瘙痒症 增生 |
| 文章编号： | 1008-0341(2006)05-0377-03 |
| 收稿时间： | 2006-06-19 |
| 修稿时间： | 2006-07-12 |
EXPRESSIONS OF c-fos AND 5-HT IN ABNORMAL SCARS AND THEIR RELATIONSHIP WITH HYPERPLASIA,ITCH AND PAIN |
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| CHEN ZHEN-YU, ZHANG WEI-NA, MIAO YUAN-XIN, et al.EXPRESSIONS OF c-fos AND 5-HT IN ABNORMAL SCARS AND THEIR RELATIONSHIP WITH HYPERPLASIA,ITCH AND PAIN[J].Medical Journal of Qilu,2006,21(5):377-379. |
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| Authors: | CHEN ZHEN-YU ZHANG WEI-NA MIAO YUAN-XIN |
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| Affiliation: | Department of Plastic and Cosmetic Surgery, The Affiliate Hospital of Qingdao University Medical College, Qingdao 266003, China |
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| Abstract: | Objective To study the expression of two mediums,i.e.c-fos and 5-HT,in abnormal scars and their relationship with hyperplasia,itch and pain.MethodsThe immunohistochemistry method was applied to study expressions of c-fos and 5-hydroxytryptamine(5-HT) in pathologic scars and normal skin.ResultsIn the itching or painful scars,c-fos and 5-HT expressions were all significantly higher than those in non-itching or painful scars and normal skin(F=19.86,17.61;q=5.43-(8.84);P<0.01);the expression of c-fos in non-itching or painful scars was higher than that with normal skin(q=3.41,P<(0.01)),while 5-HT expression was of no difference(P>0.05).ConclusionThe high expressions of c-fos and 5-HT may induce itching and painful symptoms of abnormal scars,and c-fos may contribute to the formation of the abnormal scars. |
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| Keywords: | scar proto-oncogene proteins c-fos serotonin pain pruritus hyperplasia |
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