涎腺多形性腺瘤的病理及免疫组化研究

本文对60例大小涎腺的多形性腺瘤进行病理形态分析,并选择其中30例和正常涎腺10例对组织中角蛋白、肌动蛋白和S-100蛋白进行免疫组化定位观察。研究结果提示涎腺多形性腺瘤起源于涎腺闰管壁上具有双向分化潜能的干细胞,是属于单一外胚层肿瘤,而非多胚层来源的。

Pathlogical and Immunohistochemical Studies of Pleomorphic Adenoma of the Salivary Glands

60 cases of pleomorphic adenoma from major and minor salivary glands were studied. Antibodies against keratin,actin and S-100 protein were used and immunohistochemical metnod was performed on tissue sections from 10 normal salivary glands and 30 pleomorphic adenomas. Tumor cells from all four differerent types of the tumor appeared to originate from the epithelial cells in the intercalated ducts of salivary glands. Since both the epithelium and myoepitheliumof the salivary gland arise from the oral ectoderm, in spite of the pleomorphic characteristics the histogenesis of this tumor is believed to be sole ectodermal in origin.