A DNA strand-nicking principle of a higher plant,<Emphasis Type="Italic">caesalpinia sappan</Emphasis> |
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Authors: | Mar?Woongchon Lee?Hyun-Tai Je?Kang-Hoon Choi?Hye-Young Email author" target="_blank">Seo?Eun-KyoungEmail author |
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Institution: | Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 110-460, Korea. |
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Abstract: | To find anticancer agents from higher plants, DNA strand-scission assay method was employed for bioassay-guided fractionation as well as for screening the crude extracts. During the screening, an ethyl acetate extracts of the heartwood of Caesalpinia sappan L. (Leguminosae) exhibited potent DNA strand-scission activity. Therefore, the ethyl acetate extracts of the dried heartwood of C. sappan was subjected to the bioassay-guided fractionation, which led to the isolation of a known compound, brazilin (1) as the active constituent. In addition, caesalpine J (2) was also isolated as an inactive constituent. |
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Keywords: | DNA strand-scission Caesalpinia sappan Brazilin |
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