Distinctive microRNA signature is associated with the diagnosis and prognosis of acute leukemia |
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| Authors: | Yuan-Dong Zhu Li Wang Chao Sun Lei Fan Dan-Xia Zhu Cheng Fang Yin-Hua Wang Zhi-Jian Zou Su-Jiang Zhang Jian-Yong Li Wei Xu |
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| Affiliation: | Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China. |
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| Abstract: | MicroRNAs (miRNAs) are of great importance in pathogenesis, diagnosis and prognosis of acute leukemia (AL). We studied five AL-related miRNAs to confirm the significance of these miRNAs in AL. Samples tested included acute myeloid leukemia (AML), 107 cases; acute lymphoblastic leukemia (ALL), 40 cases. Five AL-related miRNAs: miR-128, let-7b, miR-223, miR-181a and miR-155 expression were detected by qRT-PCR. Analysis showed that miRNA-128 expression was significantly higher in ALL (P?
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