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Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone |
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| Authors: | Jafar Farnam MD J Andrew Grant MD Brock G Guernsey Pharm D Joseph L Jorizzo MD Emil R Petrusa Ph D |
| Institution: | University of Texas Medical Branch, Departments of Internal Medicine and Dermatology, Galveston, Texas, USA |
| Abstract: | We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr. In a double-blind, placebo-controlled study, cimetidine alone was at least as effective as chlorpheniramine in relief of urticaria and angioedema. Additionally, cimetidine significantly inhibited (p less than 0.01) the wheal response to histamine when it was compared to placebo. The inhibition of wheal response to histamine by cimetidine was significantly higher (p less than 0.05) than chlorpheniramine. The presence of predominantly H2- rather than H1-histamine receptors in the cutaneous blood vessels may be responsible for the therapeutic effects of cimetidine in this patient. |
| Keywords: | Reprint requests: Jafar Farnam M D Division of Adult Allergy Department of Internal Medicine Clinical Sciences 409 University of Texas Medical Branch Galveston TX 77550 |
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