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急性心肌梗塞患者外周血T淋巴细胞表达CD25及其对刺激剂反应能力的变化
引用本文:张志方,王巍嵩,张春艳,吕品,林文健.急性心肌梗塞患者外周血T淋巴细胞表达CD25及其对刺激剂反应能力的变化[J].中国病理生理杂志,1999,15(9).
作者姓名:张志方  王巍嵩  张春艳  吕品  林文健
作者单位:中山医科大学基础医学院,广州510089
摘    要:目的:研究急性心肌梗塞患者外周血T淋巴细胞表达CD25及其对刺激剂反应能力的变化。方法:流式细胞仪技术。结果:急性心肌梗塞患者外周血淋巴细胞CD25 、CD4 和CD4 /CD8 比值明显低于对照组,CD8 高于对照组;CD3 CD25 、CD4 CD25 和CD4 CD25 /CD8 CD25 显著降低。在培养前后,CD3 CD25 表达均显著降低;在PDB刺激情况下,CD3 CD25 、CD8 CD25 表达均显著降低。结论:急性心肌梗塞患者存在细胞免疫功能紊乱,并存在对刺激剂PDB的反应能力降低。

关 键 词:心肌梗塞  T淋巴细胞亚群  抗原  CD25

Changes of CD25 expression in T-lymphocyte subsets of peripheral blood and its competence responded to activating agents in patients with acute myocardial infarction
ZHANG Zhi-Fang,WANG Wei-Song,ZHANG Chun-Yan,LU Pin,LIN Wen-Jian.Changes of CD25 expression in T-lymphocyte subsets of peripheral blood and its competence responded to activating agents in patients with acute myocardial infarction[J].Chinese Journal of Pathophysiology,1999,15(9).
Authors:ZHANG Zhi-Fang  WANG Wei-Song  ZHANG Chun-Yan  LU Pin  LIN Wen-Jian
Abstract:AIM: To observe changes of CD25 expression of T - lymphocyte subsets of peripheral blood and its competence responded to activating agents in paients with acute myocardial infaretion. METHODS: Flow cytometric analysis.RESULTS: The percentages f CD4 T - lymphocytes, CD25 and the ratio of CD4 /CD8 were significantly decreased in patients with acute myocardial infarction. The percentages of CD3 CD25 .CD4 CD25 and the ratio of CD4 CD25 /CD8 CD25 were also decreased significanily. The percentages of CD25 expression of T - lymphocytes were decreased after culture or using PDB (phorbol 12, 13 - dibutyrate). The percentages of CD25 on CD8 T - lymphocytes also decreased after using PDB. CONCLUSION: The disturbane of T - lymphocyte subsets and activated T - lymphocyte subsets were present in patients with acute myocardial infarction. There are lower competence of T - lymphocytes response to PDB in patients with acute myocardial infarction.
Keywords:Myocardial infarction  T-lymphocyte subsets  Antigens  CD25
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