结直肠肿瘤P53蛋白表达与肿瘤临床病理学特征及预后的关系

应用免疫组织化学方法观察７２例结直肠、１１例腺瘤、３０例癌旁粘主１５例正常粘膜Ｐ５３蛋白表达及其与肿瘤临床病理学特征和预后的关系。结果显示：结直肠癌Ｐ５３蛋白阳性率为５０％，腺瘤的阳性率为１８．１８％（Ｐ＜０．０５），阳性细胞主要分布在腺瘤的增生区或不典型增生区；正常粘膜、癌粘膜Ｐ５３蛋白均阴性。Ｐ５３蛋白阳性的结直肠癌多呈浸润性生长方式，且以浸润至浆膜外者居多，患者片存率较Ｐ５３蛋白阴性者（Ｐ＜

p53 protein expression in colorectal tumors as related to clinicopathological characteristics and prognosis

The expression of p53 was studied immunohistochemically in a series 72 colorectal carcinomas and 11 colorectal adenomas. The results are as follows:50% of the carcinomas and 18.18% of the adenomas showed positive staining(P<0.05). p53 positive foci in the adenoma were found in proliferative areas and dysplastic areas. In all cases examined,p53protein staining was negative in normal colorectal epithelium and adjacent mucosa. The p53protein positive cancers went on invasive growth frequently and most of them penetrated serous membrane,The prognosis was worse in the cases of colorectal carcinomas with p53expression than in those without,the 5-year survial rates being 35. 82%and 62.49%,respectively(P<0.05).No correlation was found between p53 expression in colorectal cancers and the tumor histologic grade,stromal responses,lymph node metastases and Dukes stage.