芦丁对去势大鼠脂质过氧化的影响

目的　研究芦丁 (rutin)对去势大鼠脂质过氧化及抗氧化系统的影响。　方法　健康雌性 SD大鼠 5 0只 ,按体重随机分为 5组 :A组 (假手术组 )、B组 (去势组 )、C组 (去势 大豆异黄酮组 )、D组 (去势 芦丁低剂量组 )和 E组 (去势 芦丁高剂量组 )。每组 10只 ,饲以实验合成饲料。实验期为 90 d。　结果　 B组大鼠血清 SOD活力较其他四组明显下降 (P<0 .0 5 ) ,MDA含量高于其他四组 (P<0 .0 5 ) ,而其他四组 SOD活力、MDA含量差别无显著性 ,且各组大鼠肝脏脂褐质 (L ipofuscin)含量差别没有显著性 (P>0 .0 5 )。　结论　芦丁对去势大鼠脂质过氧化有抑制作用 ,可抑制去势后大鼠抗氧化系统抗氧化能力的下降

Influence of Rutin on Lipid Peroxidation in Ovariectomized(OVX) Rats

Objective The research was to study the influence of rutin on lipid peroxidation and antioxidation system in ovariectomized(OVX) rats. Methods 50 SD rats were divided randomly and equally into 5 groups according to the weight.i.e. A(sham)? B(OVX rats)?C (OVX SI)?D(OVX Rutin low dose)?E(OVX Rutin high dose). All rats were fed with experiment diet. The experiment period was 90 days. Result Group B(OVX): the SOD activities of serum was significantly lower than that of the other 4 groups(P<0.05), the MDA was higher than that of the other 4 groups (P<0.05) and the discrepancy of liver lipofuscin had no significance (p>0.05). Conclusion Rutin could inhibit the decreasing of the antioxidation activities of antioxidant system and could inhibit lipid peroxidation of OVX rats.