局部晚期直肠癌同步放化疗前后血浆D-二聚体和高密度脂蛋白对疗效评价的意义

目的分析同步放化疗前后局部晚期直肠癌患者血浆D-二聚体和高密度脂蛋白胆固醇(HDL-C)水平的变化在疗效评价中的意义。方法采用胶乳增强免疫比浊法和直接法测定106例局部晚期直肠癌患者同步放化疗前后血浆D-二聚体和HDL-C水平的变化,并与96例健康体检者做对照。结果与健康体检者相比,局部晚期直肠癌患者的血浆D-二聚体水平明显升高(P0.01),HDL-C水平明显降低(P0.01)。同步放化疗后有效组D-二聚体水平明显降低(P0.01),HDL-C水平明显升高(P0.01),差异有统计学意义。同步放化疗后无效组血浆D-二聚体水平明显升高(P0.05),HDL-C水平明显降低(P0.01)。结论局部晚期直肠癌患者同步放化疗前后血浆D-二聚体和高密度脂蛋白的水平变化可为疗效评价提供依据。

Clinical significance of plasma D-dimer and high-density lipoprotein level before and after concurrent chemoradiotherapy in patients with advanced rectal cancer

Objective To explore the clinical significance of plasma D-dimer and high density lipoprotein（HDL）level before and after concurrent chemoradiotherapy in patients with advanced rectal cancer.Methods The plasma Ddimer and HDL were detected in 106patients with advanced rectal cancer and 96normal controls before and after concurrent chemoradiotherapy.Results The plasma D-dimer level was distinctly higher in patients than that in normal controls（P〈 0.01）.HDL level was significantly lower in patients than that in normal controls（P〈 0.01）.The level of plasma D-dimer in valid group significantly decreased after concurrent chemoradiotherapy（P 〈0.01）,whereas in the invalid group significantly increased（P〈 0.05）.The levels of HDL in valid group signicantly increased after concurrent chemoradiotherapy（P〈0.01）,but HDL in the invalid group decreased significantly（P〈0.01）.Conclusion The level of plasma D-dimer and HDL may provide the basis for the therapeutic effect in patients with advanced rectal cancer undergoing concurrent chemoradiotherapy.