复方丹参输卵管灌注液治疗阻塞性输卵管的量效关系初步研究

目的 观察复方丹参输卵管灌注液对阻塞性输卵管再通疗效,探讨其最佳用量及量效关系.方法 50例输卵管阻塞患者,采用随机对照临床研究,用同轴导管行输卵管介入再通术,再通成功后对照组20例灌注丹参注射液（丹参注射液5ml＋生理盐水5ml）,研究组A、B、C组不同组别各10例,灌注不同剂量的复方丹参输卵管灌注液（A组：复方丹参输卵管灌注液2ml＋生理盐水8ml;B组：复方丹参输卵管灌注液5ml＋生理盐水5ml;C组：复方丹参输卵管灌注液8ml＋生理盐水2ml）.在患者术后第12个月行输卵管造影观察通畅率,随访1年内受孕率.结果 研究组B组的再通成功率最高,对照组次之,然后是研究组A组和研究组C组.术后12个月随访输卵管通畅率、通而不畅率及再闭塞率,研究组通而不畅率和再闭塞率较对照组低,其中研究组B组最低,差异有统计学意义（P〈0 05）.结论 丹参浓度过高和过低会影响再通成功率,复方丹参输卵管灌注液能显著降低再粘连导致的通而不畅率及再闭塞率.

Primary study of dose-effect relationship between Compound Danshen Tubal Perfusion and fallopian tube obstruction

Objective To observe the curative effect of Compound Danshen Tubal Perfusion （CDTP） on fallopian tube obstruction, as well as to explore the best dose and dose-effect relationship. Methods 50 fallopian tube obstruction pa- tients were enrolled in this study after successful fallopian tube recanalization. Patients treated with CDTP were divided into 3 groups according to different dosage of CDTP （Group A：2ml;Group B ：5ml;Group C ：8ml）. Patients in the control group were treated with Danshen injection （ Danshen injection 5ml ＋ normal saline 5ml）. A 12 months follow-up survey was performed to evaluate the rate of tubal patency and pregnancy rate within 1 year. Results The group B has the highest success rate of reca- nalization ,the control group took the second place, then group is the team in group A and group C. After 12 months of follow-up of fallopian tube patency rate,jammed and occlusion rate,which of the study group was lower than those of control group, and the group B was the lowesLand the difference was statistically significant（P 〈 0.05）. Conclusion Salvia miltiorrhiza concen- tration too high or too low will affect the success rate of recanalization, and compound salvia mihiorrhiza tubal perfusion liquid can significantly reduce the jammed and occlusion rate caused by adhesion.