| 氟桂利嗪添加治疗难治性癫痫的疗效观察及其逆转P-糖蛋白的表达 |
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| 引用本文： | 徐敏,喻霞云,胡小伟,顾国浩,董万利.氟桂利嗪添加治疗难治性癫痫的疗效观察及其逆转P-糖蛋白的表达[J].苏州大学学报(自然科学版),2009,29(3):521-523. |
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| 作者姓名： | 徐敏 喻霞云 胡小伟 顾国浩 董万利 |
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| 作者单位： | 徐敏,董万利(苏州大学附属第一医院神经内科,江苏苏州,215006);喻霞云,顾国浩(苏州大学附属第一医院检验科,江苏苏州,215006);胡小伟(苏州大学附属第一医院神经内科江苏苏州,215006) |
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| 基金项目： | 苏州大学附属第一医院面上科研项目 |
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| 摘 要： | 目的了解氟桂利嗪添加治疗难治性癫痫患者的临床疗效与逆转多药耐药基因（MDR1）表达的关系。方法42例难治性癫痫患者在原抗癫痫药不变的基础上应用氟桂利嗪添加冶疗,12周后评价临床疗效。同时用ELISA法检测患者氟桂利嗪添加治疗前后血清P-糖蛋白（PGP）,并和正常对照组10人比较。结果氟桂利嗪添加治疗难治性癫痫的总有效率达52.5%。难治性癫痫患者血清PGP水平显著高于正常对照组,且治疗后血清PGP水平较治疗前明显下降,差异均有统计学意义（分别P〈0.01和〈0.05）。结论氟桂利嗪添加治疗难治性癫痫有效,其抗癫痫机制可能与逆转PGP表达有关。
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| 关 键 词： | 氟桂利嗪 癫痫 多药耐药基因 P-糖蛋白 |
A Study on the Efficiency and the Expression of PGP of Flunarizine as Add-on Therapy for Intractable Epilepsy Patients |
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| Institution: | XU Min , YU Xia-yun , HU Xiao-wei , GU Guo-hao , DONG Wan-li (1. Dept of Neurology, 2. Dept of Laboratory Research, the First Hospital Affiliated to Soochow University, Jiangsu Suzhou 215006, China) |
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| Abstract: | Objective To explore the relationship between the efficiency of flunarizne as add-on therapy for intractable epilepsy （IE） and the level of PGP in the serun of IE patients. Methods Fortytwo IE patients received flunarizine as add-on therapy,ELISA was used to test PGP in the serum of IE patients with, and compared with healthy subjects. Results The rate of efficience of flunarizine as addon therapy for IE patients was 52.5%,the level of PGP in serum of IE patients group were significantly higher than that in the normal control group,and the level of PGP was significantly decreased after the flunarizine taken as add-on therapy. Conclusion Flunarizine as add-on therapy for IE patients was efficience and the efficience may be related to the level of PGP in serum of IE patients |
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| Keywords: | flunarizine epilepsy multidrug resistance gene P-glycoprotein |
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