Chicken fetal antigens: role as cell surface receptors for Sindbis virus hemagglutinin |
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| Authors: | B G Sanders K M Wan K Kline R F Garry H R Bose |
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| Institution: | 1. Department of Zoology, The University of Texas at Austin, Austin, Texas 78712, USA;2. Department of Microbiology, The University of Texas at Austin, Austin, Texas 78712, USA |
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| Abstract: | Sindbis virus attaches to and agglutinates red blood cells from fetal and developing chickens that express chicken fetal antigens (CFA). Erythrocytes from adult chickens that do not express CFA do not contain the receptor site for the Sindbis virus hemagglutinin. The attachment of Sindbis virus to erythrocytes of different avian species indicates that Sindbis virus attachment occurs only when a specific CFA determinant, CFA determinant 9, is expressed. Erythrocytes reacted with antiserum directed against CFA determinant 9 fail to attach to or to be agglutinated by Sindbis virus. These results explain the failure of Sindbis virus to agglutinate adult chicken erythrocytes and identify the receptor for the Sindbis virus hemagglutinin. |
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