| 齐拉西酮与氯氮平治疗女性难治性精神分裂症对照研究 |
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| 引用本文： | 张帆,康建华,钱俊,李哲.齐拉西酮与氯氮平治疗女性难治性精神分裂症对照研究[J].山东精神医学,2009,22(2). |
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| 作者姓名： | 张帆 康建华 钱俊 李哲 |
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| 作者单位： | 张帆,康建华,李哲(云南省精神病医院,昆明,650224);钱俊(昆明钢铁厂医院精神科)
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| 摘 要： | 目的 探讨齐拉西酮治疗女性难治性精神分裂症的疗效及安全性.方法 将80例女性难治性精神分裂症患者随机分为齐拉西酮治疗组40例,氯氮平治疗组40例,疗程均为8月.治疗前及治疗第2、4、6、8月,采用阳性和阴性症状量表(PANSS)评定临床疗效,用副反应量表(TESS)及有关实验室检查评定不良反应.结果 阳性和阴性症状量表(PANSS)评定治疗第2、4、6、8月末与治疗前比较均有统计学意义(P＜0.05),两组间比较均无统计学意义(P＞0.05);齐拉西酮组主要不良反应为恶心、轻度静坐不能、嗜睡、震颤、头痛等;氯氮平组为流涎、体重增加、嗜睡、头晕、恶心呕吐、心肌劳损等.齐拉西酮不良反应发生率为2.8%,明显低于氯氮平的19.7%,差异有统计学意义,且不良反应程度轻.结论 齐拉西酮治疗女性难治性精神分裂症疗效与氯氮平相当,不良反应较氯氮平轻,服药依从好,可作为女性难治性精神分裂症的首选药物.
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| 关 键 词： | 齐拉西酮 氯氮平 难治性精神分裂症 |
A control study of ziprasidone vs clozapine in the treatment of female refractory schizophrenia |
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| ZHANG Fan,KANG Jianhua,QIAN Jun,et al..A control study of ziprasidone vs clozapine in the treatment of female refractory schizophrenia[J].Shangdong Archives of Psychiatry,2009,22(2). |
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| Authors: | ZHANG Fan KANG Jianhua QIAN Jun |
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| Institution: | ZHANG Fan,KANG Jianhua,QIAN Jun,et al. The Mental Hospital of Yunnan Province,Kunming 650224,China |
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| Abstract: | Objective To explore the curative effect and safety of ziprasidone in the treatment of female refractory schizophrenia. Methods A total of 80 female refractory schizophrenics were randomly divided into ziprasidone (n=40)group and clozapine (n=40) group for the treatment of 8 months. The curative effect was assessed with PANSS, and side effects with TESS, and other experimental assessments before treatment and in the 2nd, 4th,6nd and 8th month after treatment.Results There were significant differences of PAN... |
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| Keywords: | Ziprasidone Clozapine Refractory schizophrenia |
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