慢性尿酸性肾病动物模型研究及中医药对其的影响

近年来，慢性尿酸性肾病的实验研究逐渐增多，人们主要从基因重组、抑制尿酸排泄、促进血尿酸产生几方面来复制动物模型。中医药在降低血尿酸、调整细胞因子水平、延缓肾间质纤维化方面显现出较好疗效，但尚待进一步加大对中药或其提取成分的研究。本文就上述内容进行了综述。

Researches on the Establishment of Chronic Uratic Nephropathy Models and the Effect of TCM on these Models

Following contents were reviewed in this article: More and more experimental studies related with chronic uratic nephropathy were carried out in recent years. In most of these studies, the animal models were established mainly from viewpoints of gene recombination, urinary uric acid inhibition and blood uric acid production promoting. TCM showed good effects in lowering blood uric acid, regulating levels of cytokines and postponing interstitial fibrosis. However, further studies on Chinese herbs and their extracts is necessary.