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New Polymorph Form of Dexamethasone Acetate
Authors:Ronaldo Pedro da Silva  Mateus Felipe Schuchter Ambrósio  Luciana Almeida Piovesan  Maria Clara Ramalho Freitas  Daniel Lima Marques de Aguiar  Bruno Araújo Cautiero Horta  Eugenio Kahn Epprecht  Rosane Aguiar da Silva San Gil  Lorenzo do Canto Visentin
Affiliation:1. Universidade Federal do Rio de Janeiro, Campus de Xerém, Estrada de Xerém, N° 27, Xerém, Duque de Caxias, Rio de Janeiro 25245-390, Brazil;2. Pontifícia Universidade Católica do Rio de Janeiro, Departamento de Engenharia Industrial, Rua Marquês de São Vicente, 225, Rio de Janeiro, RJ, 22451-900, Brazil;3. NanoBusiness Informação e Inovação Ltda, Polo Tecnológico de Xerém, Prédio 32, Av. Nossa Senhora das Graças, 50, Xerém, Duque de Caxias, Rio de Janeiro 25250-020, Brazil;4. Universidade Federal Fluminense, Instituto de Física, Laboratório de difração de raios X(LDRX-UFF), Av. Gal. Milton Tavares de Souza, Campus Praia Vermelha, Niterói, RJ, 24210-346, Brazil;5. Universidade Federal do Rio de Janeiro, Escola de Belas Artes, Av. Pedro Calmon 500, Rio de Janeiro, RJ, 21941-901, Brazil;6. Centro Universitário Augusto Motta, Av. Paris 84, Rio de Janeiro, Rio de Janeiro 21041-020, Brazil;7. Universidade Federal do Rio de Janeiro, Instituto de Química, Av. Athos da Silveira Ramos, 149, Rio de Janeiro, RJ, 21941-611, Brazil
Abstract:A new monohydrated polymorph of dexamethasone acetate was crystallized and its crystal structure characterized. The different analytical techniques used for describing its structural and vibrational properties were: single crystal and polycrystal X-ray diffraction, solid state nuclear magnetic resonance, infrared spectroscopy. A Hirshfeld surface analysis was carried out through self-arrangement cemented by H-bonds observed in this new polymorph. This new polymorph form appeared because of self-arrangement via classical hydrogen bonds around the water molecule.
Keywords:polymorph  crystal structure  molecular modeling  X-ray polycrystal diffractometry and C-13 CPMAS NMR
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