Modeling and Prediction of Drug Dispersability in Polyvinylpyrrolidone-Vinyl Acetate Copolymer Using a Molecular Descriptor期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Modeling and Prediction of Drug Dispersability in Polyvinylpyrrolidone-Vinyl Acetate Copolymer Using a Molecular Descriptor

Authors:	Kevin DeBoyace Ira S. Buckner Yuchuan Gong Tzu-chi Rob Ju Peter L.D. Wildfong

Affiliation:	1. Duquesne University Graduate School of Pharmaceutical Sciences, 600 Forbes Ave, Pittsburgh, Pennsylvania 15282;2. Drug Product Development, Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064

Abstract:

Keywords:	amorphous solid dispersion QSPR structure property relationship in silico modeling calorimetry (DSC) microscopy X-ray powder diffractometry preformulation API active pharmaceutical ingredient ASD amorphous solid dispersion DSC differential scanning calorimetry HSM hot stage microscopy PDF pair distribution function PLM polarized light microscopy PVPva polyvinylpyrrolidone-vinyl acetate copolymer PXRD powder X-ray diffraction R3m atomic mass weighted 3rd-order autocorrelation index melting point of the active pharmaceutical ingredient
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