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Potentiation of neuromuscular weakness in infant botulism by aminoglycosides. |
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| Authors: | C L'Hommedieu R Stough L Brown R Kettrick R Polin |
| Affiliation: | 1. Department of Anesthesia of The Children''s Hospital of Philadelphia, Philadelphia, Pa. USA;2. Department of Pediatrics of The Children''s Hospital of Philadelphia, Philadelphia, Pa. USA;3. University of Pennsylvania School of Medicine, Philadelphia, Pa. USA;4. Department of Pediatrics of St. Christopher''s Hospital for Children and Temple University School of Medicine, Philadelphia, Pa. USA;5. Department of Neurology of St. Christopher''s Hospital for Children and Temple University School of Medicine, Philadelphia, Pa. USA |
| Abstract: | A retrospective study of ten patients with infant botulism who received gentamicin or kanamycin suggests that aminoglycoside antibiotics potentiate muscular weakness and precipitate respiratory failure as late as 27 days after onset of the disease. Although it is difficult to separate progression of the disease from the effects of antibiotics, the rapidity of deterioration following aminoglycoside treatment and the rapidity of recovery following cessation of aminoglycoside therapy is highly suggestive. A review of five patients who received only penicillin or a semisynthetic derivative of penicillin did not reveal any temporal deterioration with onset of penicillin therapy or improvement with cessation of penicillin therapy. |
| Keywords: | Reprint address: Department of Anesthesia The Children's Hospital of Philadelphia 34th St. & Civic Center Blvd. Philadelphia PA 19104. |
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