Adenosine A1 receptors mediate inhibition of cAMP formation in vitro in the pontine, REM sleep induction zone |
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Authors: | Marks Gerald A Birabil Christian G Speciale Samuel G |
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Affiliation: | Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Gerald.Marks@UTSouthwestern.edu |
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Abstract: | Microinjection of adenosine A1 receptor agonist or an inhibitor of adenylyl cyclase into the caudal, oral pontine reticular formation (PnOc) of the rat induces a long-lasting increase in REM sleep. Here, we report significant inhibition of forskolin-stimulated cAMP in dissected pontine tissue slices containing the PnOc incubated with the A1 receptor agonist, cyclohexaladenosine (10(-8) M). These data are consistent with adenosine A1 receptor agonist actions on REM sleep mediated through inhibition of cAMP. |
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Keywords: | Neural basis of behavior Biological rhythms and sleep |
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