丹那唑、罗氏内异方对实验性子宫内膜异位症大鼠血液流变性影响

目的：从血液流变学角度探讨中药治疗子宫内膜异位症的作用机制以及丹那唑不良反应的产生机制。方法：造模成功后，将大鼠分为空白组、模型组、西药组和中药组，灌胃给药1个月，然后了血，各组间进行血液流变性比较，结果：丹那唑显影响实验性大鼠模型的血液流变性,产生高粘滞状态，而中药无该不良反应。结论：丹那唑治疗子宫内膜异位症所产生的不良反应与其对血液流变性的影响有一定的关系，而中药可改善血液的高粘滞状态，中西医结合治疗子宫内膜异位症可提高疗效，减少不良反应。

EFFECTS OF LUOSHI NEIYI RECIPE AND DANAZOL ON BLOOD RHEOLOGY IN RATS WITH AUTOTRANSPLANTED ENDOMETRIUM

Objective:To explore the mechanism of treatment of endometriosis with Chinese drugs and the mechanism of adverse effects caused by danazol on blood rheology level.Method:Autologus endometrial segments were implanted in the peritoneum of rats,making experimental animal model.Rats were divided into four groups randomly:Control group,Model control group,Danazol group and Herb group,treated with normal saline,normal saline,Danazol and herb decoction respectively for one month.The effects of Chinese drugs and danazol on blood rheology of experimental rats were compared.Result:This experiment has shown that side effects of danazol might relate to its effect on blood rheology.Chinese drugs promoting blood circulation can improve hyperviscosity Syndrome.Conclusion:Endometriosis could be treated with western medicine combined with Chinese medicine,which can increase curative effect and decrease side effects.