Mannan-Modified Solid Lipid Nanoparticles for Targeted Gene Delivery to Alveolar Macrophages |
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Authors: | Wangyang Yu Chunxi Liu Yu Liu Na Zhang Wenfang Xu |
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Institution: | (1) School of Pharmaceutical Sciences, Shandong University, 44 Wen Hua Xi Road, Ji’nan, 250012, Shandong Province, People’s Republic of China |
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Abstract: | Purpose Cationic solid lipid nanoparticles (SLN) have established themselves during the past decades. They can efficiently bind DNA
directly via ionic interaction and mediate gene transfection. One major problem with SLN is the lack of cell-targeting ability.
In the present study, a mannan-based PE-grafted ligand was synthesized and used for the surface modification of DNA-loaded
cationic SLN to prepare Man-SLN-DNA. |
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Keywords: | |
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