Small-animal SPECT and SPECT/CT: application in cardiovascular research |
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| Authors: | Reza Golestani Chao Wu René A. Tio Clark J. Zeebregts Artiom D. Petrov Freek J. Beekman Rudi A. J. O. Dierckx Hendrikus H. Boersma Riemer H. J. A. Slart |
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| Affiliation: | (1) Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands;(2) Thorax Center, Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands;(3) Department of Surgery, Division of Vascular Surgery, University Medical Center Groningen, Groningen, The Netherlands;(4) Department of Clinical and Hospital Pharmacy, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30001, 9700 RB Groningen, The Netherlands;(5) Image Sciences Institute and Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Utrecht, The Netherlands;(6) Division of Cardiology, School of Medicine, University of California, Irvine, Irvine, California;(7) Faculty of Applied Sciences, Section Radiation Detection and Medical Imaging, Delft University of Technology, Delft, The Netherlands;(8) MILabs, Utrecht, The Netherlands;(9) Cardiovascular Imaging Group, University Medical Center Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands; |
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| Abstract: | Preclinical cardiovascular research using noninvasive radionuclide and hybrid imaging systems has been extensively developed in recent years. Single photon emission computed tomography (SPECT) is based on the molecular tracer principle and is an established tool in noninvasive imaging. SPECT uses gamma cameras and collimators to form projection data that are used to estimate (dynamic) 3-D tracer distributions in vivo. Recent developments in multipinhole collimation and advanced image reconstruction have led to sub-millimetre and sub-half-millimetre resolution SPECT in rats and mice, respectively. In this article we review applications of microSPECT in cardiovascular research in which information about the function and pathology of the myocardium, vessels and neurons is obtained. We give examples on how diagnostic tracers, new therapeutic interventions, pre- and postcardiovascular event prognosis, and functional and pathophysiological heart conditions can be explored by microSPECT, using small-animal models of cardiovascular disease. |
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