| 铜绿假单胞菌对5种消毒剂抗性的研究 |
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| 引用本文： | 王玉月,史伟峰,朱永华,顾建文,季云.铜绿假单胞菌对5种消毒剂抗性的研究[J].中华医院感染学杂志,2008,18(12). |
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| 作者姓名： | 王玉月 史伟峰 朱永华 顾建文 季云 |
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| 作者单位： | 常州市第一人民医院检验科,江苏,常州,213003 |
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| 摘 要： | 目的 了解临床分离的铜绿假单胞菌对碘伏、戊二醛、氯己定、氯氧三嗪(三氯异氰尿酸)和苯扎溴铵5种消毒剂的抗性.方法 采用PhoenixTM-100系统鉴定铜绿假单胞菌和药敏试验,用液体稀释法检测碘伏、戊二醛、氯己定、氯氧三嗪和苯扎溴铵对铜绿假单胞菌的最低抑菌浓度(MIC).结果 190株铜绿假单胞菌对氨苄西林/舒巴坦、氯霉素、四环素、复方新诺明耐药率最高均＞98.0%,几乎已失去对该菌的杀菌能力;而对亚胺培南、美罗培南耐药率较低,仅为15.3%和6.8%,5种消毒剂中,铜绿假单胞菌对戊二醛和氯氧三嗪的抗性最强,MIC50分别为32 μg/ml和64μg/ml;而对氯己定、苯扎溴铵的抗性最弱,MIcso分别为1μg/ml和2.4 μg/ml;氯己定在1 MIC作用10 min,仍能产生快速而强烈的杀菌作用.结论 铜绿假单胞菌对碘伏、戊二醛、氯己定、氯氧三嗪和苯扎溴铵5种消毒剂的抗性差异有统计学意义,应合理使用消毒剂,以降低耐药菌扩散及医院感染发生.
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| 关 键 词： | 铜绿假单胞菌 消毒剂 最低抑菌浓度 |
Resistance of Pseudomonas aeruginosa Against Five Antiseptics |
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| WANG Yu-yue,SHI Wei-feng,ZHU Yong-hua,GU Jian-wen,JI Yun.Resistance of Pseudomonas aeruginosa Against Five Antiseptics[J].Chinese Journal of Nosocomiology,2008,18(12). |
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| Authors: | WANG Yu-yue SHI Wei-feng ZHU Yong-hua GU Jian-wen JI Yun |
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| Institution: | WANG Yu-yue,SHI Wei-feng,ZHU Yong-hua,GU Jian-wen,JI Yun(Changzhou No.1 Hospital,Changzhou,Jiangsu 213003,China) |
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| Abstract: | OBJECTIVE To explore the resistance of Pseudomonas aeruginosa isolated in clinic against five antiseptics involving in povidone iodine(Iodophor),glutaraldehyde,chlorhexidine,symclosene(trichloroisocyanurate) and benzalkonium bromide.METHODS The susceptibility test of P.aeruginosa was determined by PhoenixTM-100 system.Minimun inhibitory concentration(MIC) of povidone iodine,glutaraldehyde,chlorhexidine,symclosene and benzalkonium bromide was detected by liquid dilution method.RESULTS The resistant rates of ... |
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| Keywords: | Pseudomonas aeruginosa Antiseptics Minimun inhibitory concentration |
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