间歇无创通气治疗慢性阻塞性肺疾病并呼吸衰竭的临床研究

目的探讨间歇应用无创正压通气（NPPV）治疗慢性阻塞性肺疾病（COPD）并呼吸衰竭患者的疗效及并发症。方法将COPD并发呼吸衰竭患者42例随机分为两组：间歇无创通气组（A组，21例）给予常规治疗＋间歇无创通气治疗；持续无创通气组（B组，21例）给予常规治疗＋持续无创通气治疗。记录治疗24h和72h后患者的动脉血气pH、PaO2、PaCO2变化以及并发症。结果两组的有效率、血气分析值、失败率以及住院天数差异均无统计学意义（P〉0．05），副作用发生率A组较B组有明显减少（P〈0．01）。结论间歇无创正压通气与持续无创正压通气治疗COPD并呼吸衰竭疗效相似，前者并发症明显减少，患者依从性好。

Curative Effects of Intermittent Noninvasive Ventilation on COPD Patients with Respiratory Failure

Objective To explore the clinical effect of intermittent noninvasive positive pressure ventilation （NPPV） in the treatment of chronic obstructive pulmonary disease （COPD） with respiratory failure and its complications. Methods Forty-two cases were randomly divided into two groups. Group A was treated with routine method and intermittent NPPV ,whereas the group B was treated with routine method and continual NPPV. The arterial blood gas analysis（ pH,PaO2 and PaCO2 ） and complications were recorded in 24 h and 72 h respectively. Results There was no statistical difference in effective rate, value of pH, PaO2 and PaCO2, rate of failure, days of hospitalization between the both groups（ P 〉 0.05 ）. The incidence of complications in group A was significant lower compare to group B （ P 〈 0.01 ）. Conclusions Intermittent NPPV with a lower rate of complications has similar effect as continual NPPV for COPD patients with respiratory failure.