高三尖杉酯碱与5—氟尿嘧啶在青光眼滤过性手术应用中的对比研究

本文采用随机、双盲及前瞻性方法,将高三尖杉酯碱(Homoharringtonine,H.H)和5-氟尿嘧啶(5-Fluorouracil,5-FU)用于难治性青光眼滤过手术。比较了两者对滤过手术疗效的影响及其毒副作用。其中,H.H组24只眼,5-FU组23只眼。随诊10～20个月(平均18个月),研究结果显示:(1)H.H组功能性滤过泡累计百分率为84.9％,显著高于5-FU组(62.2％)(P<0.05);(2)H.H组的累计手术成功率为85.7％,显著高于5-FU组(61.1％)(P<0.05),(3)H.H组角膜上皮缺损的发生率为20.8％,低于5-FU组(52.2％)(P<0.05)。其他并发症两组间无差别。

A COMPARATIVE STUDY OF HOMOHARRINGTONINE WITH 5-FLUOROURACIL IN FILTERING SURGERY

With a prospective, randomized and double-masked control method, ho-moharringtonine(H. H) and 5-Fluorouracil (5-FU) were used in filtering surgery. We compared the effect and side effect of H. H with those of 5-FU. 24 eyes were in H. H group and 23 eyes in 5-FU group. An average follow-up of 18 months revealed: (1) the cumulative percentage of functioning bleb in H. H group (84. 9%) was significantly higher than that in 5-FU group (62. 2%) (P<0. 05); (2) the cumulative surgical success rate in H. H group (85. 7%) was significantly higher than that in 5-FU group (61. 1%) (P<0. 05); (3) the rate of corneal eraosion in H. H group (20. 8%) was significantly lower than that in 5-FU group (52. 2%) (P<0. 05), the difference of other complications between H. H group and 5-FU group was not significant.