| 心脏靶向超声造影剂空气白蛋白微球的研究(1) |
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| 引用本文： | 陈志良,陈树元,金伟军,单友亮,周日红,侯连兵. 心脏靶向超声造影剂空气白蛋白微球的研究(1)[J]. 中国生化药物杂志, 1999, 0(1) |
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| 作者姓名： | 陈志良 陈树元 金伟军 单友亮 周日红 侯连兵 |
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| 作者单位： | 第一军医大学附属南方医院药学部!广州510515 |
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| 摘 要： | 按正交设计筛选了用发射超声能量合成白蛋白空气微球的较佳制备工艺，并对微球的形态、粒径与粒径分布、稳定性、安全性和显影效果进行了系统研究。结果表明：微球的平均直径为 ４．２±０． ２ μｍ，平均浓度为（３．５±１．２）×１０８／ｍｌ。９２．５％的微球直径小于１０μｍ，微球在２℃～５℃条件下能稳定储存１２个月，经兔外用静脉注射后能顺利通过肺微循环到达左心室致使左心室靶向超声显影。
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| 关 键 词： | 声学显影剂 白蛋白微球 制备 |
Study on Air-filled Albumin Microspheres: an Echo-contrast Agent for Heart Targeting (1) |
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| Chen Zhiliang,Chen Shuyuan,Jin Weijun,San Youliang,Zhou Rihong,Hou Lianbin. Study on Air-filled Albumin Microspheres: an Echo-contrast Agent for Heart Targeting (1)[J]. Chinese Journal of Biochemical Pharmaceutics, 1999, 0(1) |
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| Authors: | Chen Zhiliang Chen Shuyuan Jin Weijun San Youliang Zhou Rihong Hou Lianbin |
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| Affiliation: | Chen Zhiliang,Chen Shuyuan,Jin Weijun,San Youliang,Zhou Rihong,Hou Lianbin Department of Pharmacy,Nanfang Hospital,First Military Medical University |
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| Abstract: | An optimun procedure was established by orthogonal test for preparing air-filled mierospheres with sonicated albumin. The quality, stability, safety and efficacy of the microspheres were studied. The results showed that the mean size was 4. 2± 0. 2 μm, the mean concentration was (3. 5±1. 2) × 10 8/ml, the diameter of 92. 5 %. of the microspheres was less than 10 μm, its stability could be kept at 2℃-5℃ for 12 months. Transpulmonary left ventricular cavity opacification could be reached to 3+ grade after peripheral venous injection in rabbits. |
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| Keywords: | Air-filled albumin microspheres Preparation Sonication |
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