补肾密骨片结合骨髓移植对桡骨延迟愈合的实验研究

目的]观察补肾密骨片结合经皮自体骨髓移植对骨折延迟愈合治疗后的骨密度和生物力学性能影响。方法]预制新西兰大耳白兔骨延迟愈合模型，将75只兔随机分为四组：A组20只，饲料中加入补肾密骨片，骨延迟愈合区注入自体红骨髓2ml；B组20只，饲料中加入补肾密骨片，骨延迟愈合区不注入自体红骨髓；C组20只，饲料中不加补肾密骨片，骨延迟愈合区注入自体红骨髓；D组15只，造成骨延迟愈合模型后，饲料中不加补肾密骨片，骨延迟愈合区不注人自体红骨髓。治疗后12周处死动物取材，行骨密度及生物力学测试。结果]骨密度及生物力学测试均显示A组骨愈合优于B、C、D组。结论]补肾密骨片结合经皮自体骨髓移植治疗骨折延迟愈合的骨组织的骨密度及生物力学强度优于单一骨髓移植或中药治疗。

Study of radius delayed union on bone mineral density and biomechanics treated by Chinese traditional medicine and bone marrow transplantation

Objective] To study the effect of Chinese traditional medicine and bone marrow transplantation on treating delayed union. Method]The model of delayed union in 75 rabbits was made and divided into 4 groups. Group A, 20 rabbits treated with Chinese traditional medicine and red marrow 2 ml ; Group B, 20 rabbits treated with Chinese traditional medicine ; Group C, 20 rabbits treated with red marrow; Group D, 15 rabbits treated with nothing. X-ray in the 4th, 8th and 12th weeks were observed after treating. And bone mineral density and biomechanics were observed in 12ts week after trenting. Result] X-ray revealed that group A heal earlier than group B, C and D. At the same time, bone mineral density and biomechanics in group A was better than others. Conclusion] The treatment of delayed union by Chinese traditional medicine and bone marrow transplantation is one of effective means.