左旋氨氯地平联合依那普利治疗肾性高血压的临床效果观察

目的 观察左旋氨氯地平联合依那普利治疗肾性高血压的临床疗效.方法 将2010年3月-2013年2月间入选的76例肾性高血压患者按照随机数字表分为观察组（n=41例）与对照组A（n=35例）,观察组患者予左旋氨氯地平联合依那普利方案,对照组予硝苯地平联合依那普利方案,疗程8周,疗程结束后对比两组血压与肾功能变化.结果 ①两组治疗后血压值较治疗前明显下降（P＜0.05）,观察组患者血压值较之对照组下降更为明显,差异有统计学意义（P＜0.05）.②两组患者治疗后Scr、BUN、24h尿蛋白定量均较治疗前下降,其中观察组BUN、24 h尿蛋白定量与治疗前水平,差异有统计学意义（P＜0.05）,且24 h尿蛋白定量明显低于对照组水平（P＜0.05）.结论 左旋氨氯地平联合依那普利治疗肾性高血压降压效果明显,且能一定程度上保护肾功能,具有临床推广价值.

Observation on the Clinical Efficacy of Levamlodipine Besylate and Enalapril in the Treatment of Renal Hypertension

Objective To observe the clinical efficacy of levamlodipine besylate and enalapril in the treatment of renal hyperten- sion. Methods 76 admitted renal hypertension patients from March, 2010 to February, 2013 were randomly divided into observa- tion group （n=41cases） and control group （n=35cases）. The observation group was treated with levamlodipine besylate and enalapril scheme, the control group was treated with nifedipine and enalapril scheme, for 8 weeks, a course of treatment. And after the treat- ment, the blood pressure value and renal function were compared between 2 groups. Results ①Blood pressure values of 2 groups were both obviously lower than those pre-treatment （P〈0.05）, the blood pressure values of observation group patients decreased more significantly than those of the control group, the difference was statistically significant（P〈0.05）. ② Set, BUN and 24h urinary protein of 2 groups of patients after treatment decreased than those pre-treatment, BUN and 24 h urinary protein of the observation group had statistically significant difference compared with those pre-treatment （P〈0.05）, and 24 h urine protein were significantly lower than that of the control group（P〈0.05）. Conclusion Levamlodipine besylate and enalapril have good effect on renal hyperten- sion, and can protect renal function to a certain extent, which have the value of clinical promotion.