上皮-钙黏蛋白、糖链抗原125检测在卵巢上皮性肿瘤鉴别与预后评估中的意义

目的：探讨上皮-钙黏蛋白（E-cad）、糖链抗原125（CA125）检测在卵巢上皮性肿瘤鉴别与预后评估中的价值。方法：分别采用酶联免疫吸附试验和电化学发光免疫分析法检测卵巢上皮性交界性肿瘤患者、卵巢上皮性癌患者、卵巢上皮良性肿瘤患者和健康人群血清E-cad、CA125水平,并分析卵巢肿瘤患者血清E-cad、CA125相关性。结果：卵巢肿瘤患者血清E-cad、CA125明显高于对照组,差异具有统计学意义（P〈0.05）;卵巢癌组血清E-cad、CA125水平明显高于交界组和良性组,交界组CA125水平明显高于良性组,差异具有统计学意义（P〈0.05）;但两组间E-cad水平相比,差异无统计学意义（P〉0.05）;交界组、卵巢癌组患者中,晚期患者血清E-cad、CA125水平明显高于早期患者,卵巢癌组中复发或未控患者血清E-cad、CA125水平明显高于未复发患者,差异具有统计学意义（P〈0.05）。相关性分析显示卵巢肿瘤患者血清E-cad水平与CA125无明显相关性（r=0.057,P=0.673）。结论：E-cad可与CA125相互补充,联合检测可作为预测卵巢肿瘤恶性程度、分化程度和预后的良好指标。

Value of E-cadherin,carbohydrate antigen 125 detection in identification and prognosis pre- diction of patients with ovarian epithelial tumor

Objective： To explore value of E-cadherin, carbohydrate antigen 125 detection in identification and prognosis prediction of patients with ovarian epithelial tumor. Methods： Enzyme-linked immunosorbent assay and chemiluminescence im- munoassay methods were used to detect serum E-cad, CA125 levels in patients with epithelial ovarian borderline tumor, epi- thelial ovarian cancer, ovarian epithelial benign tumor and healthy persons, and correlation of serum E-cad with CA125 in epithelial ovarian tumors patients were also analyzed. Results： In ovarian cancer patients, E-cad and CA125 levels were significant- ly higher than those in control group （P〈0.05）; In ovarian carcinoma group serum E-cad, CA125 level were significantly higher than those of border group and benign group （P〈0.05）. In border group CA125 levels were significantly higher than those in benign group （P〈0.05）, but there was no significant difference in levels of E-cad between the two groups （P〉 0.05）. In border group and ovarian carcinoma group, serum E-cad, CA125 levels in advanced patients were significantly higher in patients at early stage （P〈0.05）. In recurrent ovarian cancer group or uncontrolled group, serum E-cad, CA125 levels were significantly higher in patients without recurrence （P〈0.05）. Correlation analysis showed no correlation of CA125 with E-cad （r=0. 057,P=0. 673）. Conclusion： E-cad and CA12 can complement each other, and they can be used as good indicator in prediction of ovarian tumors malignancy degree, differentiation and prognosis.