苄星青霉素治疗妊娠期梅毒的疗效探讨

目的研究探讨苄星青霉素对妊娠合并梅毒的治疗效果。方法选取2009年2月—2012年6月在该院血清学检查确诊为妊娠期梅毒的孕妇60例,分为孕期治疗组30例和对照组30例,治疗组患者在孕期使用苄星青霉素进行抗梅毒治疗1~2个疗程,对照组患者未采取任何治疗措施。比较两组患者的妊娠结局以及先天性梅毒的发生情况。结果治疗组的孕妇在使用苄星青霉素后,妊娠结局比对照组好。相比较对照组而言,治疗组分娩出正常新生儿的例数要多,且新生儿先天性梅毒的概率要低,流产和死胎的发生率也比较低。两组之间差异统计学意义（P〈0.05）。结论妊娠期合并梅毒的患者在孕期使用苄星青霉素进行治疗后,有效地降低了新生儿的死亡率和先天性梅毒的发生概率,是一种对于妊娠期梅毒的有效治疗方案,值得推广。

Study on the Curative Effect of Benzathine Penicillin in the Treatment of Syphilis During Pregnancy

Objective To study the treatment effect of benzathine penicillin in the treatment of syphilis in pregnancy. Methods 60 cases of pregnant women diagnosed with syphilis during pregnancy confirmedly by serologic test in our hospital from February, 2009 to June, 2012 were divided into treatment group and control group with 30 cases in each. The patients of the treatment group were given benzathine penicillin during pregnancy for the treatment of syphilis for 1 to 2 periods of treatment, while the patients in the control group were not given any treatment measures. The pregnancy outcome and occurrence of congenital syphilis were compared between the two groups of patients. Results The pregnancy outcome of the treatment group was better than that of the control group. Compared with the control group, the treatment group had more normal neonatal cases, lower risk of neonatal congenital syphilis and lower incidence of miscarriage and stillbirth. The differences between the groups were statistically significant（P0.05）. Conclusion The treatment of benzathine penicillin for patients with syphilis during pregnancy effectively reduce the mortality rate of neonates and the incidence of congenital syphilis, which is an effective treatment for syphilis during pregnancy and worth promoting.