In vitro conversion of proinsulin to insulin by cathepsin B in isolated islets and its inhibition by cathepsin B antibodies |
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| Authors: | Renu Bansal Nafees Ahmad Jalil R Kidwai |
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| Institution: | (1) Division of Biochemistry, Central Drug Research Institute, 226001 Lucknow, U.P., India |
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| Abstract: | Summary Purified bovine cathepsin B, when incubated with isolated rat islets of Langerhans, completely converts proinsulin to insulin
as demonstrated by the incorporation of14C-leucine into islet proteins, releasing lysine as the only basic amino acid. Cathepsin B antibodies raised in rabbit inhibited
the above conversion.
CDRI Communication No. 2703 |
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| Keywords: | Cathepsin B Cathepsin B antibodies Islets of Langerhans Proinsulin-insulin |
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